Branklyn-Garten in Ost-Schottland

Pleiotropic Functions of the Organic Solute Transporter Ost-Ost

The heteromeric organic solute transporter alpha-beta (Ost -Ost ) is expressed at relatively high levels on the basolateral membrane of enterocytes, where it plays a critical role in the intestinal absorption of bile acids and the enterohepatic circulation. However, this transporter is also expressed in nearly all human tissues, including those that are not normally thought to be involved in bi...

On the ost of using

OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids.

The organic solute and steroid transporter, Ost alpha-Ost beta, is an unusual heteromeric carrier that appears to play a central role in the transport of bile acids, conjugated steroids, and structurally-related molecules across the basolateral membrane of many epithelial cells. The transporter's substrate specificity, transport mechanism, tissue distribution, subcellular localization, transcri...

Ost -Ost is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver

Ballatori N, Fang F, Christian WV, Li N, Hammond CL. Ost -Ost is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Am J Physiol Gastrointest Liver Physiol 295: G179–G186, 2008. First published May 22, 2008; doi:10.1152/ajpgi.90319.2008.—Mice deficient in the organic solute transporter (Ost)subunit of the heteromeric organic solute and steroid transpo...

On Feferman's operational set theory OST

We study OST and some of its most important extensions primarily from a proof-theoretic perspective, determine their consistency strengths by exhibiting equivalent systems in the realm of traditional set theory and introduce a new and interesting extension of OST which is conservative over ZFC.